LEVOFLOXACIN ORAL CHALLENGE TEST

Abstract

Drug allergy is one type of adverse reaction to drugs and encompasses a spectrum of hypersensitivity reactions with heterogeneous mechanisms and clinical presentations. It has been defined by the British Society for Allergy and Clinical Immunology (BSACI) as 'an ADR with an established immunological mechanism' ^1,2 . Diagnostic procedures in allergy diagnosis can be classified into  the patient's history, in vivo skin testing, in vitro laboratory tests  and provocation tests ³ . In situations in which there is a definite medical need for a particular agent, no suitable alternative agent exists, there are primarily two options for the patient with a drug allergy; a procedure to induce temporary drug tolerance can be performed to allow the patient to take the drug safely or a test dose or graded challenge can be administered to determine whether the patient is currently allergic to the particular drug .⁴  JMS 2016; 19(2):97-98