TO STUDY THE EFFECT OF THYROXINE DURING INTRAOPERATIVE CARDIOPULMONARY BYPASS PROCEDURE AND ITS POSTOPERATIVE EFFECT ON MORBIDITY AND MORTALITY.

Abstrakt

Background: Thyroid gland secretes two major hormones namely T4 and T3. Hypothyroid patients have reduced cardiac output, stroke volume and plasma volume. Hypothyroidism is associated with bradycardia, increased vascular resistance, narrow pulse pressure and mild hypertension.

OBJECTIVES: To study

1. the status of thyroid function test in patients planned for cardiac surgery under cardiopulmonary bypass (CPB) ,
2. the correlation of thyroid function status with postoperative course and outcome, and

• The thyroid function status of patients who underwent cardiac surgery under cardiopulmonary bypass at 3months.

STUDY DESIGN: An observational study.

PARTICIPANTS: 128 patients (>14 years) undergoing cardiac surgery under CPB for cardiovascular diseases.

METHODS: Thyroid function test were done preoperatively, on 1^st and 7^th postoperative day, and after 3 months post-surgery.

RESULTS: There was a drop in postoperative TSH on day 2 and day 7 as compared to preoperative TSH which was statistically significant. Atrial fibrillation was the most common complication which was significantly more in patients with elevated preoperative TSH. In our study mortality rate was seen to be 8%. Mortality rates were more in patients with pre-operative hypothyroidism in comparison to euthyroid patients.

CONCLUSION: Preoperative hypothyroid patients were seen to have significantly increased morbidity and mortality in postoperative period.

IMPLICATION: It is preferably to check and correct hypothyroidism preoperatively in cardio surgical patients.