Hashimotos Encephalopathy: unusual manifestation of a common disorder
Keywords:
Hashimotos Encephalopathy, Graves' disease, Autoimmune thyroiditis
Abstract
Hashimoto's encephalopathy is a steroid responsive encephalopathy usually seen in association with autoimmune thyroiditis independent of the thyroid status. However; its association with Graves’ disease is rare. Here, we present a case of HE associated with Graves’ disease. The patient presented with altered sensorium with varied psychiatric manifestations and went into rapid remission after steroid therapy.
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References
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10. Zhou JY, Xu B, Lopes J, Blamoun J, Li L. Hashimoto encephalopathy: literature review. Acta Neurol Scand. 2017 Mar;135(3):285–90.
2. Tamagno G, Celik Y, Simó R, Dihné M, Kimura K, Gelosa G, et al. Encephalopathy associated with autoimmune thyroid disease in patients with Graves’ disease: clinical manifestations, follow-up, and outcomes. BMC Neurol. 2010 Apr 28;10:27.
3. Yoneda M. [Hashimoto’s encephalopathy and autoantibodies]. Brain Nerve Shinkei Kenkyu No Shinpo. 2013 Apr;65(4):365–76.
4. Chong JY, Rowland LP, Utiger RD. Hashimoto encephalopathy: syndrome or myth? Arch Neurol. 2003 Feb;60(2):164–71.
5. Kothbauer-Margreiter I, Sturzenegger M, Komor J, Baumgartner R, Hess CW. Encephalopathy associated with Hashimoto thyroiditis: diagnosis and treatment. J Neurol. 1996 Aug;243(8):585–93.
6. Forchetti CM, Katsamakis G, Garron DC. Autoimmune thyroiditis and a rapidly progressive dementia: global hypoperfusion on SPECT scanning suggests a possible mechanism. Neurology. 1997 Aug;49(2):623–6.
7. Zettinig G, Asenbaum S, Fueger BJ, Hofmann A, Diemling M, Mittlboeck M, et al. Increased prevalence of sublinical brain perfusion abnormalities in patients with autoimmune thyroiditis: evidence of Hashimoto’s encephalitis? Clin Endocrinol (Oxf). 2003 Nov;59(5):637–43.
8. Ferracci F, Bertiato G, Moretto G. Hashimoto’s encephalopathy: epidemiologic data and pathogenetic considerations. J Neurol Sci. 2004 Feb 15;217(2):165–8.
9. Shaw PJ, Walls TJ, Newman PK, Cleland PG, Cartlidge NE. Hashimoto’s encephalopathy: a steroid-responsive disorder associated with high anti-thyroid antibody titers--report of 5 cases. Neurology. 1991 Feb;41(2 ( Pt 1)):228–33.
10. Zhou JY, Xu B, Lopes J, Blamoun J, Li L. Hashimoto encephalopathy: literature review. Acta Neurol Scand. 2017 Mar;135(3):285–90.
Published
2020-06-22
How to Cite
1.
Bhat J, Dar J, Bhat M, Qureshi W. Hashimotos Encephalopathy: unusual manifestation of a common disorder. jms [Internet]. 2020Jun.22 [cited 2026Oct.2];23(2):43-6. Available from: http://ano.jmsskims.org/index.php/jms/article/view/749
Section
Case Reports
