Biochemical parameters in coronavirus-19 disease: markers of disease severity or mere indicators of viral inflammation!
Abstract
Background: Covid-19 disease has a varied clinical presentation ranging from asymptomatic to critical cases, the mortality being high in the latter. The covid-19 disease is associated with derangement of various biochemical parameters, which may correlate with the severity.
Aim: We intend to study the relation of various biochemical parameters with the severity of the disease and their role in monitoring the progression.
Methods: A total of 530 patients were included in the study which included 148 mild cases and 382 severe/critical cases. Biochemical parameters were checked on days 1, 5, 10, and 14, and results were correlated with the disease severity.
Results: Leucopenia and lymphopenia were more common in the mild group as compared to leucocytosis, which was more common in the severe group. Additionally, serum creatinine, d-dimer, alkaline phosphatase, serum bilirubin, and serum ferritin were also significantly raised in the severe group. Lactate dehydrogenase was seen as significantly common in the mild group, but serial levels correlated with the disease progression.
Conclusion: Derangement of various biochemical parameters helps in assessing the severity and progression of the covid-19 disease.
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